In general most php.ini settings can be left with their default values.
You should ensure the following settings are as below:
short_open_tag = On
There is a single module (imdb parser) which has a short open tag in 1.22, fixed in latest development release. This requirement will be removed when 1.23 is released.
magic_quotes_gpc = Off
magic_quotes_runtime = Off
Magic quotes are deprecated from PHP 5.3.0 and removed from 6.0.0 so better get used to not using them.
variables_order = "EGPCS"
Required to enable detection of SwissMonitor service.
session.gc_maxlifetime = 86400
Large session timeout to avoid losing page history.